A phase 2 randomized, double-masked, placebo controlled study of novel nonsystemic kinase inhibitor TOP1630 for the treatment of dry eye disease

Taylor, Mike; Ousler, George; Torkildsen, Gail; Walshe, Claire; Fyfe, Matthew CT; Rowley, Adele; Webber, Steve; Sheppard, John D; Duggal, Ajay

Clinical Ophthalmology 2019:13 261–275


Effect of Narrow Spectrum Versus Selective Kinase Inhibitors on the Intestinal Proinflammatory Immune Response in Ulcerative Colitis
Biancheri, Paolo MD; Foster, Martyn R. BSc; Fyfe, Matthew C. T. PhD; MacDonald, Thomas T. PhD; Sirohi, Sameer MSc; Solanke, Yemisi BSc; Wood, Eleanor MB BChir; Rowley, Adele PhD; Webber, Steve PhD; Walshe, Claire A. PhD
Inflammatory Bowel Diseases: June 2016 - Volume 22 - Issue 6 - p1306-1315

Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders
Hagan, Suzanne; Fyfe, Matthew C. T.; Ofori-Frimpong, Boatemaa; Oliver, Katherine; Foster, Martyn R.; Sirohi, Sameer; Solanke, Yemisi; Doughty, Michael; Rowley, Adele; Taylor, Mike; Webber, Steve; Walshe, Claire A.
Investigative Opthalmology & Visual Science: March 2018 - Volume 59 - p1443-1453

A review paper has also been published by Matthew C.T. Fyfe, Non-systemic Intestine-Targeted Drugs. In: Geoff Lawton and David R. Witty, editors, Progress in Medicinal Chemistry, Vol. 55, Amsterdam: Elsevier, 2016, pp. 1-44



TopiVert presented the following poster at ARVO, 29 April - 3 May 2018 in Honolulu, HI

TopiVert presented the following poster at the 13th Congress of ECCO, 14-17 February 2018 in Vienna

TopiVert presented the following 2 posters at ARVO, 7-11 May 2017 in Baltimore, MD

TopiVert presented the following 3 posters at the leading gastrointestinal industry conference: 12th Congress of ECCO, 15-18 February 2017 in Barcelona 

TopiVert presented the following 5 posters at the 11th Congress of ECCO, 16-19 March 2016 in Amsterdam

TopiVert presented the following poster at the 22nd Congress of UEGW, 18-22 October 2014 in Vienna

TopiVert presented the following poster at the 11th International Symposium ISOPT, 19-22 June 2014 in Reykjavik

TopiVert presented the following poster at DDW, 18-21 May 2013 in Orlando, FL